After the famine entire Rajputana was affected by epidemics like cholera, plague and deprivation of food. In this health crisis 20 percent population lost their lives in Rajputana. Mewar State also lost a large number of population. At this time, the nobles of Mewar requested the Maharana Shambhu Singh to leave Udaipur but Maharana refused this request and decided to live in Mewar to service community. The State Government learnt from past experiences and prioritized relief operations in Mewar under the leadership of Maharana Shambhu Singh. A large number of people from various areas of Rajputana took shelter in Mewar. The citizens of Mewar showed kindness and helped the refugees. They tried to provide all possible amenities like medicine, food and shelter. Maharana of Mewar gave order to Pradhan (Prime Minister of Mewar) Kesari Singh Kothari for food distribution and grains in needy population, who worked daily for their livelihood. Mewar Government also worked for health improvement in those areas where affected people and refugees were inhabited. The State exempted all the taxes and duties. After the prevention of the epidemic, Maharana of Mewar gave the grant of Rs. 11000 for resettlement of the refugees coming from different areas of Rajputana. The first State Dispensary appears to have been opened at the Udaipur in 1862 CE by Maharana Shambhu Singh and he provided accommodation for patients in 1864 CE. In 1869-70 CE another small hospital was opened at Kherwara for the public. This hospital was maintained from a monthly grant from the Maharana.

In 1878-1879 CE entire Rajputana faced a critical situation due to heavy rainfall and then subsequent famine and epidemics. But due to the effective efforts of Maharana Sajjan Singh (r. 1874-1884 CE) the people in Mewar remained safe compared to the previous disasters. However, 50 percent of the animal wealth was lost in Mewar. During the reign of Maharana Sajjan Singh, the United Free Church of Scotland Mission established a Shepherd Mission Hospital in 1877 CE. Shepherd Mission Hospital, presently Dhanmandi Hospital, was supported by Reverend Dr. Shephard at Udaipur City. In the course of the next decade the Sajjan Hospital, presently Kunwarpada Dispensary, was established. Walter Female Hospital was started in recognition of then the Political Agent of Mewar Colonel Walter were established at Udaipur. Walter Female Hospital, presently Naturopathy Hospital, was constructed in 1888 near Ghas Ghar with initial strength of 40 beds. He also started small pox vaccination in Udaipur.Thus in 1881, there were 7 medical institutions in the State including the hospital attached to the Jail for the treatment of sick prisoners and jail servants.

Due to the past disasters experiences, Maharana Fateh Singh (r. 1884 - 1930 CE) introduced development policy and started construction work. These policies were prepared for the public in further disasters along with the development of Mewar. In 1890-1892, due to the spread of cholera, smallpox in the neighboring states of Mewar people took shelter in Mewar. Maharana of Mewar established Emergency Relief Fund to provide necessary assistance and support to public. Vaidhya-Hakims (A man who practice indigenous Medicare) were appointed from all areas of Mewar for medical facilities and arrangements. In 1896 CE, around 620 deaths recorded in Udaipur from cholera. In 1899 CE, after famine cholera and smallpox epidemics began to spread. The Mewar government adopted the process of 'Isolation'. Medical arrangements were ensured by keeping infected patients away from the city and the sanitation system was started smoothly in Udaipur city. Maharana Fateh Singh replaced Sajjan Hospital, due to its small building and narrow road, by the Lansdowne Hospital in recognition of Viceroy of India Lord Lansdowne in July 1894 CE inside the Hathi Pol area of Udaipur. Lansdowne Hospital, presently Ayurveda Hospital at Harven Ji Ka Khurra, Hathi Pol, was the main Hospital of the city with provision of 60 beds. The State possessed 20 Hospitals and the Dispensaries until 1901 CE, 13 were maintained solely by the Maharana, 3 by the Government of India, 2 partly by the Government and private subscription, 1 by the Mission and 1 by the Gosainji Maharaj of Nathdwara. On 8th November 1885 Viceroy of India Lord Dufferin visited Udaipur and the new building of Walter Female Hospital was unveiled by Lady Dufferin. A Lunatic Asylum, outside Brahma Pol, was constructed by Maharana Fateh Singh in 1899 - 1900.

Maharana Bhupal Singh (r. 1930 - 1955 CE) gave the grant to maintain the District Dispensaries and Aushdhalayas. The Earl of Willingdon, Viceroy of India (1931 to 1936 CE) inaugurated the Willingdon Hospital, outside Hathi Pol, during his visit to Udaipur on 6th December 1932. After independence this Hospital was renamed as Maharana Bhupal Government Hospital. During the year 1942 there were 5 Hospitals, 26 Dispensaries, 2 anti-rabic centres and 1 lunatic asylum in Mewar State. The Government of Mewar decide to start a separate TB Hospital in 1943-43 and the old military barracks were converted into a hospital of 25 beds.